Understanding the evolution of antibody affinity maturation and … – News-Medical.Net
Antibodies are essential for immune defense and safeguarding against bacteria, viruses, and other foreign entities. Produced by B cells, these protein molecules offer the potential for treating cancers, autoimmune disorders, and infectious diseases.
However, modified therapeutic antibodies can see a reduction in efficacy as the human immune system recognizes them as foreign substances. Two techniques have been devised to overcome this obstacle: antibody humanization and affinity maturation.
The biotech industry has experienced a revolution in the last 10-20 years due to advancements in antibody humanization and affinity maturation. These techniques have enabled the development of exceptionally potent therapeutic antibodies with a broad spectrum of applications in treating various diseases.
Before antibody humanization and affinity maturation, therapeutic antibody development was slow and challenging. It relied on less effective non-human sources, leading to unwanted immune responses…
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source: https://news.oneseocompany.com/2023/05/29/understanding-the-evolution-of-antibody-affinity-maturation-and-news-medicalnet_2023052945376.html
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