Protein Wears Prada – Mirage News

Just as wearing a new outfit can cause us to assume a different persona, so a chemical tag “worn” by a protein can make that molecule unrecognizable. An entire wardrobe of tags – called protein modifications, because they modify the protein’s original sequence – helps the thousands of proteins in our bodies perform their versatile tasks, but the modifications make life difficult for scientists and physicians seeking to identify these vital molecules. Prof. Yifat Merbl’s lab at the Weizmann Institute of Science has taken up the challenge of simultaneously detecting large numbers of modified proteins – together with all their trappings.

Wearing such tags, known as protein modifications, can be as “life changing” as donning a superhero getup or a tiara. The tags can affect nearly all of the proteins’ essential properties – including stability, location in the cell and their binding to other molecules, and they might mark diseased proteins for destruction or determine how well a…

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