Androgen-modifying treatments extend last disease activity in older … – Healio
SAN DIEGO — Older men with MS who used androgen-modifying treatments experienced last disease activity at a later age compared with women and men who refrained from these treatments, according to a poster at ACTRIMS 2023.
“Men, and specifically older men, are underrepresented in the MS research population since [disease] frequency is lower in men,” Nur Neyal, MD, a postdoctoral research fellow in the departments of neurology and radiology at the Mayo Clinic, told Healio in an interview.
Neyal and colleagues examined disease activity in older men with MS who were on androgen-modifying treatments (AMTs) for benign prostate hyperplasia or prostate cancer, as testosterone is known to interfere with neuroinflammatory pathways.
Utilizing Mayo Clinic’s institutional search engine, researchers identified 143 individuals with MS on AMTs and included 41 for analysis, of whom 15 had MS disease activity after AMT initiation (mean age, 67.1 years). They were matched by age at last clinical visit…
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